Flunixin meglumin

Research use only, not for human use.

Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.

Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.(In Vitro):flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages.flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages.(In Vivo):Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2.

flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages.flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages. Cell Viability Assay Cell Line:RAW 264.7 murine macrophages Concentration:10, 100, 300, and 1000 μM Incubation Time:2 hours Result:Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1,000 μM (P=0.01).

Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2. Animal Model:Male sheep injected with Carrageenan Dosage:1.1 mg/kg Administration:Intravenous injection; 1.1 mg/kg; once Result:Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h.

NIH 10250

Chromatin/Epigenetic

COX

COX-1| COX-2

Inflammation/Immunology

——

42461-84-7

491.46

C21H28F3N3O7

>98% (HPLC)

Ethanol: 8 mg/mL (16.27 mM); Water: 98 mg/mL (199.4 mM); DMSO: 98 mg/mL (199.4 mM)

O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC

(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate

(-20℃)

With Ice Pack

≥ 2 years